Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
نویسندگان
چکیده
In the supporting information section of this paper, the structures of oltipraz and safranin in Figure S1 were incorrect. The corrected fi gure may be found at Copyright: © 2007 Kuntz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
منابع مشابه
Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
BACKGROUND Schistosomiasis--infection with helminth parasites in the genus Schistosoma, including S. mansoni--is a widespread, devastating tropical disease affecting more than 200 million people. No vaccine is available, and praziquantel, the only drug extensively utilized, is currently administered more than 100 million people yearly. Because praziquantel resistance may develop it is essential...
متن کاملThioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum
BACKGROUND Schistosomiasis remains a major public health concern affecting billions of people around the world. Currently, praziquantel is the only drug of choice for treatment of human schistosomiasis. The emergence of drug resistance to praziquantel in schistosomes makes the development of novel drugs an urgent task. Thioredoxin glutathione reductase (TGR) enzymes in Schistosoma mansoni and s...
متن کاملCheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug resistance. The multifunctional protein, thioredoxin glutathione reductase (TGR), an essential enzyme for the survival of the pathogen in the redox en...
متن کاملInhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects.
Schistosomiasis is a parasitic disease affecting over 200 million people currently treated with one drug, praziquantel. A possible drug target is the seleno-protein thioredoxin-glutathione reductase (TGR), a key enzyme in the pathway of the parasite for detoxification of reactive oxygen species. The enzyme is a unique fusion of a glutaredoxin domain with a thioredoxin reductase domain, which co...
متن کاملDetermining Potential Inhibitor(s) of Thioredoxin Glutathione Reductase, Key Enzyme of Schistosoma Mansoni Parasite
Schistosomiasis is a parasitic worm disease that affects more than 200 million people worldwide, and the drug praziquantel remains the only treatment. Recently there have been reports of patients showing signs of resistance to praziquantel. Consequently, there is an urgent need to develop a new drug to serve as an alternative to praziquantel. In this experiment, we will determine potential inhi...
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ورودعنوان ژورنال:
- PLoS Medicine
دوره 4 شماره
صفحات -
تاریخ انتشار 2007